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Within their range of applicability both
2021-03-17
Within their range of applicability, both approaches matched the phase boundaries and yields generally to within the measurement error. The approaches matched the phase compositions generally to within 11 wt% or less with the average absolute deviations listed below: One advantage of the proposed a
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Several models show the MAPK pathway involving p as the
2021-03-17
Several models show the MAPK pathway involving p38 as the AH 7614 receptor pathway in pro-inflammatory responses, with the ERK pathway involvement primarily devoted to cell growth and differentiation events (Lai et al., 2001, Widmann et al., 1999). The results of the current study would contradict
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br Criteria for ER targeted fluorescent probes br Survey of
2021-03-16
Criteria for ER-targeted fluorescent probes Survey of fluorescent probes Proposed approach to high affinity fluorescent steroidal ER probes Our proposed approach to the development of a new generation of fluorescent estrogen receptor imaging agents employs many of the elements present in th
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EphB appears to be a
2021-03-16
EphB4 appears to be a low-affinity receptor for rhEpo based on the biochemical data. The concentration of rhEpo used for the biological experiments (50 IU/ml) corresponds to 10–15 nM, which is 1% to 2% of the KD value (KD = 881 nM) for the binding of rhEpo to EphB4, as measured in the MST assay. The
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Another milestone in the field is the de novo
2021-03-16
Another milestone in the field is the de novo discovery of EPAC2 and EPAC1 specific inhibitors through fluorescence-based HTS assays. Due to the excellent EPAC/PKA selectivity of dopamine receptor , it has been widely applied as a useful chemical probe to discriminate EPAC related signaling pathway
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Results of the present study demonstrate that OHC
2021-03-16
Results of the present study demonstrate that 25-OHC treatment of THP-1 monocytes induced vimentin intermediate filament reorganization to more cortical structures and a polarized phenotype (Fig. 5). Vimentin is the major intermediate filament protein present in leukocytes and plays an important rol
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The relatively less well studied encodes the
2021-03-16
The relatively less well-studied encodes the E2 type SUMO-conjugating enzyme. In plants, the SCE family members play roles in abiotic stress responses. An E2 enzyme, SaSce9, from plays roles in salinity and drought stress responses (). Furthermore, SCE can respond to heat stress in rice (). Howeve
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CGP 42112 Ubiquitin activating enzyme activates ubiquitin by
2021-03-16
Ubiquitin-activating enzyme activates ubiquitin by a three-step process with ATP as a cofactor (Chen et al., 2011, Haas and Rose, 1982, Haas et al., 1982). We demonstrated that ATP is required for mRFP-Ub–E1 formation under non-reducing conditions (Fig. 2A). A time course of radioactive ATP producti
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Advances in the total chemical synthesis
2021-03-16
Advances in the total chemical synthesis of ubiquitin have enabled the efficient synthesis of new and improved ubiquitin-based reagents. Using an optimized linear synthesis, ubiquitin can now be easily obtained in high yield and purity [35]. Using this synthetic methodology, ubiquitin can be functio
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Nowadays colorimetric assay has been applied in detecting DN
2021-03-16
Nowadays, colorimetric assay has been applied in detecting DNA MTase activity. Li et al. used DNA modified gold nanoparticles (AuNPs) coupled with enzyme-linkage reactions to detect the activity of methylases [20]. In a previous study, our group presented a label-free colorimetric method, using unmo
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br Enzymes repairing alkylated DNA br Induction of the Ada
2021-03-16
Enzymes repairing alkylated DNA Induction of the Ada regulon Methylated Ada is a strong activator for ada and alkA promoters. Although much weaker than the methylated form, unmethylated Ada acts alone as an activator for ada and alkA promoters. In contrast, the unmethylated protein present in
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In contrast DAG phosphorylation to PA by
2021-03-16
In contrast, DAG phosphorylation to PA by diacylglycerol kinases (DGKs) represents a quantitatively minor metabolic pathway, but is generally regarded as a main disposal pathway for “signaling” DAG. PA produced by DGKs is an intermediate of the synthesis of CDP-DAG, cardiolipin and PI. However, PA i
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br Application of the screening system
2021-03-16
Application of the screening system for ITP-binding proteins Inosine is a nucleoside with hypoxanthine as a base. Inosine nucleotides are relatively abundant in human CPI-455 because inosine monophosphate (IMP) is a general precursor molecule for the de novo synthesis of AMP and GMP or a product
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69 8 sale Among the CYP enzymes CYP D has been
2021-03-16
Among the CYP450 enzymes, CYP2D has been considered a crucial protein that involves in the metabolism of xenobiotics and drugs (Zanger and Schwab, 2013). Some isoforms of the CYP2D subfamily have been well characterized, such as CYP2D6 due to its clinical importance and CYP2D14 in black cattle (Hama
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Another well established visceral action of CRF and urocorti
2021-03-16
Another well-established visceral action of CRF and urocortin administered peripherally is the long-lasting lowering of blood pressure observed in various species ranging from rodents to humans [22]. Existing evidence suggests that the hypotensive action of CRF and urocortin is mediated by the inter
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